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Title : Janus-Faced Wnt Signaling
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Janus-Faced Wnt Signaling

Deregulated Wnt signaling leads to certain types of cancer, particularly colorectal cancer.  But Wnt signaling is two-faced, Janus-faced, and certain neurological diseases are characterized by the opposite problem: repression of Wnt signaling.  There, inhibition of Wnt signaling enhances disease in a mouse model of Alzheimer’s.

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