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Title : Microbiome And Sex-Specific Brain Development
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Microbiome And Sex-Specific Brain Development

The microbiome can affect microglia development in a sex-specific manner, which has implications for brain development and function.  This occurs in mice, but mouse and human microglia exhibit enough similarities that we can suspect that the same situation holds for humans as well.  This once again demonstrates the profound impacts of microglia, as well as that of sex-specific developmental differences.  Abstract:

Microglia are embryonically seeded macrophages that contribute to brain development, homeostasis, and pathologies. It is thus essential to decipher how microglial properties are temporally regulated by intrinsic and extrinsic factors, such as sexual identity and the microbiome. Here, we found that microglia undergo differentiation phases, discernable by transcriptomic signatures and chromatin accessibility landscapes, which can diverge in adult males and females. Remarkably, the absence of microbiome in germ-free mice had a time and sexually dimorphic impact both prenatally and postnatally: microglia were more profoundly perturbed in male embryos and female adults. Antibiotic treatment of adult mice triggered sexually biased microglial responses revealing both acute and long-term effects of microbiota depletion. Finally, human fetal microglia exhibited significant overlap with the murine transcriptomic signature. Our study shows that microglia respond to environmental challenges in a sex- and time-dependent manner from prenatal stages, with major implications for our understanding of microglial contributions to health and disease.

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