Title : More On Macular Degeneration
link : More On Macular Degeneration
More On Macular Degeneration
Macular degeneration is a major cause of blindness, and researchers have discovered a new mechanism whereby retinal pigmented epithelium degenerates, casing disease. These discoveries can lead to new treatments for this disease. Abstract:
Geographic atrophy is a blinding form of age-related macular degeneration characterized by retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency, resultant accumulation of endogenous Alu-retroelement RNA, and NLRP3-inflammasome activation. How the inflammasome is activated in this untreatable disease is largely unknown. Here we demonstrate that RPE degeneration in human-cell-culture and mouse models is driven by a noncanonical-inflammasome pathway that activates caspase-4 (caspase-11 in mice) and caspase-1, and requires cyclic GMP-AMP synthase (cGAS)-dependent interferon-β production and gasdermin D-dependent interleukin-18 secretion. Decreased DICER1 levels or Alu-RNA accumulation triggers cytosolic escape of mitochondrial DNA, which engages cGAS. Moreover, caspase-4, gasdermin D, interferon-β, and cGAS levels were elevated in the RPE in human eyes with geographic atrophy. Collectively, these data highlight an unexpected role of cGAS in responding to mobile-element transcripts, reveal cGAS-driven interferon signaling as a conduit for mitochondrial-damage-induced inflammasome activation, expand the immune-sensing repertoire of cGAS and caspase-4 to noninfectious human disease, and identify new potential targets for treatment of a major cause of blindness.
Thus Article More On Macular Degeneration
That's an article More On Macular Degeneration This time, hopefully can give benefits to all of you. well, see you in posting other articles.
You are now reading the article More On Macular Degeneration with the link address https://letslifes.blogspot.com/2018/03/more-on-macular-degeneration.html
0 Response to "More On Macular Degeneration"
Post a Comment