Orchid Derivative Against Breast Cancer Cells

Orchid Derivative Against Breast Cancer Cells - Hallo friendsLET'S HEALTHY LIFE, In the article you read this time with the title Orchid Derivative Against Breast Cancer Cells, We have prepared this article for you to read and retrieve information therein. Hopefully the contents of postings Article cough, Article diabetes, Article diseases, Article in general, Article Phytotherapy, Article skin diseases, We write this you can understand. Alright, good read.

Title : Orchid Derivative Against Breast Cancer Cells
link : Orchid Derivative Against Breast Cancer Cells

Read too


Orchid Derivative Against Breast Cancer Cells

An orchid derivative exhibits activity against breast cancer cells by inhibiting Wnt signling; abstract:

BACKGROUND:
Gigantol is a bibenzyl compound derived from several medicinal orchids. This biologically active compound has been shown to have promising therapeutic potential against cancer cells, but its mechanism of action remains unclear.
METHODS:
The inhibitory effect of gigantol on Wnt/β-catenin signaling was evaluated with the SuperTOPFlash reporter system. The levels of phosphorylated low-density lipoprotein receptor related protein 6 (LRP6), total LRP6 and cytosolic β-catenin were determined by Western blot analysis. The expression of Wnt target genes was analyzed using real-time PCR. Cell viability was measured with a MTT assay. The effect of gigantol on cell migration was examined using scratch wound-healing and transwell migration assays.
RESULTS:
Gigantol decreased the level of phosphorylated LRP6 and cytosolic β-catenin in HEK293 cells. In breast cancer MDA-MB-231 and MDA-MB-468 cells, treatment with gigantol reduced the level of phosphorylated LRP6, total LRP6 and cytosolic β-catenin in a dose-dependent manner, resulting in a decrease in the expression of Wnt target genes Axin2 and Survivin. We further demonstrated that gigantol suppressed the viability and migratory capacity of breast cancer cells.
CONCLUSION:
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells.



Thus Article Orchid Derivative Against Breast Cancer Cells

That's an article Orchid Derivative Against Breast Cancer Cells This time, hopefully can give benefits to all of you. well, see you in posting other articles.

You are now reading the article Orchid Derivative Against Breast Cancer Cells with the link address https://letslifes.blogspot.com/2018/05/orchid-derivative-against-breast-cancer.html

Subscribe to receive free email updates:

Related Posts :

0 Response to "Orchid Derivative Against Breast Cancer Cells"

Post a Comment