Title : TGIF1 In Colorectal Cancer
link : TGIF1 In Colorectal Cancer
TGIF1 In Colorectal Cancer
TGIF1 is another molecular factor discovered to promote colorectal cancer, apparently by upregulating the deregulated Wnt signaling found in most cases of that disease. This discovery may point to novel therapeutic approaches targeting this factor. Abstract:
Colorectal cancer (CRC) is one of the most common cancers, but the mechanisms underlying its initiation and progression are largely unknown. TGIF1 (TGFB induced factor homeobox 1) is a transcriptional corepressor that belongs to the three-amino acid loop extension (TALE) superclass of atypical homeodomains. It has been reported that TGIF1 is highly expressed in mammary cancer and non-small cell lung cancer and can enhance tumor progression. However, the role of TGIF1 in colorectal cancer remains unknown. Here, we report that TGIF1 is significantly upregulated in colorectal cancers, and its high expression predicts poor prognosis. Overexpression of TGIF1 markedly promotes the proliferation of colorectal cancer cells both in vivo and in vitro. In addition, TGIF1 activates Wnt/β-catenin signaling, and the homeodomain is indispensable for Wnt activation and β-catenin interaction. Taken together, our results suggest that TGIF1 is a novel colorectal tumor promoter and indicate that TGIF1 enhances colorectal cancer tumorigenesis through activating Wnt signaling.
Thus Article TGIF1 In Colorectal Cancer
That's an article TGIF1 In Colorectal Cancer This time, hopefully can give benefits to all of you. well, see you in posting other articles.
You are now reading the article TGIF1 In Colorectal Cancer with the link address https://letslifes.blogspot.com/2018/10/tgif1-in-colorectal-cancer.html
0 Response to "TGIF1 In Colorectal Cancer"
Post a Comment