Modeling Chemical Communication - Hallo friendsLET'S HEALTHY LIFE, In the article you read this time with the title Modeling Chemical Communication, We have prepared this article for you to read and retrieve information therein. Hopefully the contents of postings Article cough, Article diabetes, Article diseases, Article in general, Article Phytotherapy, Article skin diseases, We write this you can understand. Alright, good read.

Title : Modeling Chemical Communication
link : Modeling Chemical Communication

Modeling Chemical Communication

Metabolite-protein interactions can be used to model chemical communication in the body. Abstract:

Metabolite-protein interactions control a variety of cellular processes, thereby playing a major role in maintaining cellular homeostasis. Metabolites comprise the largest fraction of molecules in cells, but our knowledge of the metabolite-protein interactome lags behind our understanding of protein-protein or protein-DNA interactomes. Here, we present a chemoproteomic workflow for the systematic identification of metabolite-protein interactions directly in their native environment. The approach identified a network of known and novel interactions and binding sites in Escherichia coli, and we demonstrated the functional relevance of a number of newly identified interactions. Our data enabled identification of new enzyme-substrate relationships and cases of metabolite-induced remodeling of protein complexes. Our metabolite-protein interactome consists of 1,678 interactions and 7,345 putative binding sites. Our data reveal functional and structural principles of chemical communication, shed light on the prevalence and mechanisms of enzyme promiscuity, and enable extraction of quantitative parameters of metabolite binding on a proteome-wide scale.

Thus Article Modeling Chemical Communication

That's an article Modeling Chemical Communication This time, hopefully can give benefits to all of you. well, see you in posting other articles.

You are now reading the article Modeling Chemical Communication with the link address https://letslifes.blogspot.com/2019/02/modeling-chemical-communication.html

Tweet

Subscribe to receive free email updates: