Protein Glycosylation Targeting Immunotherapy - Hallo friendsLET'S HEALTHY LIFE, In the article you read this time with the title Protein Glycosylation Targeting Immunotherapy, We have prepared this article for you to read and retrieve information therein. Hopefully the contents of postings Article cough, Article diabetes, Article diseases, Article in general, Article Phytotherapy, Article skin diseases, We write this you can understand. Alright, good read.

Title : Protein Glycosylation Targeting Immunotherapy
link : Protein Glycosylation Targeting Immunotherapy

Protein Glycosylation Targeting Immunotherapy

Another approach for anti-cancer immunotherapy, abstract:

Protein glycosylation provides proteomic diversity in regulating protein localization, stability, and activity; it remains largely unknown whether the sugar moiety contributes to immunosuppression. In the study of immune receptor glycosylation, we showed that EGF induces programmed death ligand 1 (PD-L1) and receptor programmed cell death protein 1 (PD-1) interaction, requiring β-1,3-N-acetylglucosaminyl transferase (B3GNT3) expression in triple-negative breast cancer. Downregulation of B3GNT3 enhances cytotoxic T cell-mediated anti-tumor immunity. A monoclonal antibody targeting glycosylated PD-L1 (gPD-L1) blocks PD-L1/PD-1 interaction and promotes PD-L1 internalization and degradation. In addition to immune reactivation, drug-conjugated gPD-L1 antibody induces a potent cell-killing effect as well as a bystander-killing effect on adjacent cancer cells lacking PD-L1 expression without any detectable toxicity. Our work suggests targeting protein glycosylation as a potential strategy to enhance immune checkpoint therapy.

Thus Article Protein Glycosylation Targeting Immunotherapy

That's an article Protein Glycosylation Targeting Immunotherapy This time, hopefully can give benefits to all of you. well, see you in posting other articles.

You are now reading the article Protein Glycosylation Targeting Immunotherapy with the link address https://letslifes.blogspot.com/2019/02/protein-glycosylation-targeting.html

Tweet

Subscribe to receive free email updates: